A procedure for the analysis of S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine in human urine

Å. Norström National Board of Occupational Safety and Health, Research Department, Chemical Unit in Umeå, P.O. Box 6104, S-900 06, Umeå, Sweden

B. Andersson National Board of Occupational Safety and Health, Research Department, Chemical Unit in Umeå, P.O. Box 6104, S-900 06, Umeå, Sweden

J.-O. Levin National Board of Occupational Safety and Health, Research Department, Chemical Unit in Umeå, P.O. Box 6104, S-900 06, Umeå, Sweden

Abstract

1. Analytical methods for mercapturic acids, the end-products of gluthathione metabolism of the industrial solvents toluene and o-xylene (i.e., S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine), added to human urine have been developed.

2. The sensitivity is 2ng/μl (R.S.D. = ±13%) and 1 ng/μl (R.S.D.= ±6.4%) urine for S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine, respectively, when using the h.p.l.c. method.

3. The corresponding sensitivities for the g.l.c.-mass spectrometric method are 0.5 and 0.3 ng/μl urine, respectively.

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A procedure for the analysis of S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine in human urine

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A procedure for the analysis of S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine in human urine

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