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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 7
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Original Article

Metabolism of methapyrilene by rat-liver homogenatc

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Pages 671-680 | Received 13 Aug 1985, Published online: 30 Sep 2009
 

Abstract

1. The metabolism of methapyrilene(I) in rat-liver 9000g supernatant fraction produced four new metabolites positively identified by comparison of g.l.c. retention times and mass-spectral fragmentation patterns with those of authentic materials. These compounds are 2-thiophene-methanol(VI), 2-thiophenecarboxylic acid(VII), N-2-pyridyl-N′-dimethylethylenediamine(IX) and 2-aminopyridine(X).

2. In addition, the previously known metabolite 2-[(2-thienylmethyl)amino]-pyridine(VIII) was also positively identified.

3. Six other metabolites were tentatively identified by analysis of the mass-spectral fragmentation patterns of both the trimethylsilyl and the tertiary butyldimethylsilyl derivatives of each compound. These compounds are tentatively identified as: normethapyrilene(II), (hydroxypyridyl)-methapyrilene(XII), methapyrilenamide(XIV), (hydroxypyridyl)-normethapyrilene(XVI), (hydroxypyridyl)-desmethylmethapyrilenamide(XVII), and (hydroxypyridyl) methapyrilenamide(XVIII).

4. Quantification of II, VI-X, XII and XIV account for approx. 65% of the metabolized methapyrilene.

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