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Abstract
1. Eight volunteers were each given 300mg of erythromycin lactobionate by i.v. infusion over 15 min in the presence and absence of chronic dosing with slow-release theophylline.
2. Pharmacokinetic profiles were obtained for theophylline in the presence and absence of erythromycin and for erythromycin in the presence and absence of theophylline.
3. A very small, clinically unimportant, but statistically significant increase occurred in mean (± S.E.M.) serum theophylline concentration from 4.9 ± 0.3 mg/1 to 5.2±0.3 mg/1 in the presence of erythromycin (P = < 0.01). The theophylline pharmacokinetic parameters did not change significantly.
4. The only changes in erythromycin pharmacokinetics were an increase in the renal excretion (0–12h) from 5.5±4.0 mg to 11.2±6.0 mg (P < 0.03) and an increase in renal clearance (0–2h) from 9.0±6.0 ml/min to 21.6±15 ml/min (P < 0.05) in the presence of theophylline.