Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction

L. S. Crouch Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Department of Pediatrics, University of Texas Health Science Center, Dallas, TX, 75235, USA

R. E. Ebel Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA

Abstract

1. The metabolism of benzo[a]pyrene (BP) by gerbil hepatic microsomes is increased following induction by phenobarbital (PB), chlordecone, mirex and 3-methylcholanthrene (3-MC).

2. By several criteria including the influence of α-naphthoflavone (α-NF) on BP-hydroxylase activity and BP-metabolite profiles, the cytochromes P-450 responsible for benzo[a]pyrene metabolism appear to be similar in microsomes isolated from PB-, chlordecone-, or mirex-treated gerbils. The cytochromes P-450 present in microsomes isolated from control animals and those treated with 3-MC are different from each other and from those present in PB, chlordecone, or mirex microsomes by the same criteria.

3. Of the inducers used, only PB induced microsomal epoxide hydrolase activity.

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Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction

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Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction

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