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Abstract
1. A methaemoglobin former, 4-aminopropiophenone (p-arninopropiophenone, PAPP), which is active only after metabolic activation in vivo, exhibits a sex difference in male Beagle dogs and bitches. Bitches produced more methaemoglobin for a given dose of PAPP than male dogs.
2. The probable reason for this difference was a lower rate of N-hydroxylation in male dogs.