Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 10
25
Views
15
CrossRef citations to date
0
Altmetric
Original Article

Metabolism of a dicofol impurity α-chloro-DDT, but not dicofol or dechlorodicofol, to DDE in mice and a liver microsomal system

&
Pages 1169-1174 | Received 30 Jul 1986, Published online: 30 Sep 2009
 

Abstract

1. The important acaricide dicofol and two related compounds, α-chloro-DDT (an impurity in dicofol) and dechlorodicofol (DCD) (a photolysis product of dicofol), as [phenyl-14C]-labelled preparations, were administered i.p. to male mice (30 mg/kg) and incubated with rat-liver microsomes alone and with NADPH, both aerobically and anaerobically, and with rat-liver cytosol alone and with glutathione.

2. α-Chloro-DDT is metabolically dechlorinated to DDE in the following systems: in vivo, based on analyses of mouse brain, fat and liver; in vitro, with anaerobic rat-liver microsomes plus NADPH; and with reduced haematin. Trace amounts of DDT are also detected in vivo in mouse liver.

3. Dicofol is reductively dechlorinated to DCD, and both compounds are metabolized to dichlorobenzophenone and dichlorobenzhydrol in vivo in the mouse tissues examined, and also in vitro exclusively with anaerobic rat-liver microsomes in the presence of NADPH. Liver cytosol with glutathione is less effective or inactive.

4. The in vivo metabolic dechlorinations of α-chloro-DDT and dicofol probably involve a reduced porphyrin in liver microsomes.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.