A kidney perfusion method for metabolism studies with chickens using propachlor as a model

K. L. Davison Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA

J. E. Bakke Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA

G. L. Larsen Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA

Abstract

1. A procedure for directly perfusing chicken kidneys in situ with xenobiotics is described.

2. When propachlor (2-chloro-N-isopropylacetanilide) or the glutathione, cysteine and mercapturic acid conjugates of propachlor were individually perfused through chicken kidneys, propachlor mercapturate was isolated from the urine and identified as an end product, indicating that all enzymes necessary for mercapturic acid formation were present in chicken kidney.

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A kidney perfusion method for metabolism studies with chickens using propachlor as a model

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A kidney perfusion method for metabolism studies with chickens using propachlor as a model

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