Metabolism of 2,6-dichlorobenzamide in rats and mice

J. E. Bakke Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA

G. L. Larsen Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA

V. J. Feil Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA

E. B. Brittebo Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA; Department of Pharmology and Toxicology, The Swedish University of Agricultural Sciences, Uppsala Biomedical Center, Box 573, S-751 23, Uppsala, Sweden

I. Brandt Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA; Department of Pharmology and Toxicology, The Swedish University of Agricultural Sciences, Uppsala Biomedical Center, Box 573, S-751 23, Uppsala, Sweden

Abstract

1. Oral doses of 2,6-dichlorobenzamide (DCB) were excreted by rats as DCB, two monohydroxy-DCBs, 2-chloro-5-hydroxy-6-(methylthio)benzamide and 2-chloro-5-hydroxy-6-[S-(N-acetyl)cysteinyl]benzamide (mercapturic acid).

2. Biliary excretion (33% of the dose), enterohepatic circulation and intestinal microfloral metabolism were involved in formation of 2-chloro-5-hydroxy-6-(methylthio)benzamide, and the mercapturic acid served as a precursor.

3. Whole body autoradiography and microautoradiography showed the accumulation of non-extractable. residues from DCB in the nasal mucosa and contents of the large intestines of rats and mice dosed with ¹⁴C-labelled DCB.

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Metabolism of 2,6-dichlorobenzamide in rats and mice

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Metabolism of 2,6-dichlorobenzamide in rats and mice

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