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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 10
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Original Article

Biotransformation of 1,4-Cineole, a Monoterpene Ether

Y. Asakawa Faculty of Pharmaceutical Science, Tokushima Bunri University, Yamashirocho, Tokushima, 770, Japan
,
M. Toyota Faculty of Pharmaceutical Science, Tokushima Bunri University, Yamashirocho, Tokushima, 770, Japan
&
T. Ishida Hiroshima Institute of Technology, Itsukaichicho, Saekiku, Hiroshima, 731-51, Japan
Pages 1129-1134 | Received 08 Dec 1987, Accepted 02 Jun 1988, Published online: 30 Sep 2009
 
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Abstract

1.The metabolism of 1,4-cineole, a monoterpene ether, was studied in the rabbit.

2.Four neutral and one acidic metabolites were isolated from the urine and shown to be 9-hydroxy-1,4-cineole, 3,8-dihydroxy-1,4-cineole, 8,9-dihydroxy-1,4-cineole, 1,4-cineole-8-en-9-ol and 1,4-cineole-9-carboxylic acid.

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