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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 8
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Original Article

The transfer and metabolism of 7-ethoxycoumarin and androstenedione during the in vitro perfusion of the human placental lobule

, , , &
Pages 905-917 | Received 18 Aug 1987, Accepted 19 Feb 1988, Published online: 30 Sep 2009
 

Abstract

1. The in vitro metabolism of 7-ethoxycoumarin in the perfused placental lobule has been investigated and compared with that of androstenedione.

2. Perfusion studies showed that the placental lobule was capable of sustaining the metabolism of 7-ethoxycoumarin to 7-hydroxycoumarin for at least one hour but at a considerably lower rate than that for the conversion of androstenedione to oestrone under the same conditions.

3. Following perfusion with androstendione disproportionately large amounts of oestrone were found in the maternal outflow and ostradiol in the foetal outflow.

4. Appreciably more testosterone was formed when the foetal side of the lobule was perfused with androstenedione than when the maternal side was perfused.

5. The data indicate that the human placenta has only a limited capacity for the metabolism of xenobiotics.

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