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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 8
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Original Article

Metabolism of 14C-thymoxamine in rat and man

, , , , , & show all
Pages 919-928 | Received 16 May 1987, Accepted 14 Feb 1988, Published online: 30 Sep 2009
 

Abstract

1. After oral administration of 14C-thymoxamine to rat and man the total 14C excreted in urine and faeces was determined.

2. Six metabolites were isolated from the excreta of man and rat by chemical extraction and identified by g.l.c.-mass spectral analyses.

3. Two other metabolites, highly polar and resistant to enzymic hydrolysis, were isolated by extraction on XAD2 resin and h.p.l.c. analysis. These two metabolites were identified by n.m.r. and by mass spectrometry in the fast atomic bombardment mode.

4. These two major metabolites of thymoxamine in man and rat have been identified and characterised as the sulphate conjugates of desacetyl-thymoxamine and N-monodesmethyl-desacetyl-thymoxamine.

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