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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 8
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Original Article

Intermediary metabolism of 2,6-dichlorobenzonitrile (dichlobenil) in chickens and growth of chickens fed dichlobenil

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Pages 941-948 | Received 07 Sep 1987, Accepted 03 Mar 1988, Published online: 30 Sep 2009
 

Abstract

1. Ten 14C-labelled metabolites were isolated from either bile (6 metabolites) or urine (7 metabolites) from chickens given single oral doses of 2,6-dichlorobenzo[14C]nitrile (14C-dichlobenil). All metabolites were benzonitriles with the following ring substituents: two Cl, OH (two isomers); Cl, two OH; Cl, OH, SH; Cl, OH, S-glutathione; Cl, OH, S-cysteinylglycine; Cl, OH, S-cysteine; and Cl, OH, S-(N-acetyl)cysteine.

2. 2-(S-Glutathionyl)-3-hydroxy-6-chlorobenzo[14C]nitrile perfused through chicken kidneys in situ was excreted in urine from the perfused kidney (44% dose) as 2-mercapto-3-hydroxy-6-chlorobenzonitrile.

3. Dichlobenil (2,6-dichlorobenzonitrile) was fed at 0, 75, 150 or 225 p.p.m. in the diet to broiler and laying strains of cockerels to determine biological activity. Feed consumption and growth were not affected, but liver and kidney weights were higher in chicks fed the dichlobenil. The percentage of lipid or nitrogen in the livers and kidneys from chicks fed dichlobenil did not differ from controls and histological or ultrastructural changes were not observed in these tissues.

Note

No warranties are herein implied by the U.S. Department of Agriculture.

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