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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 4
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Research Article

Effect of Sparteine and Quinidine on the Metabolism of Methoxyphenamine by Cunninghamella Bainieri

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Pages 445-452 | Received 18 Oct 1988, Accepted 20 Nov 1988, Published online: 22 Sep 2008
 

Abstract

1. The fungus C. bainieri, incubated for 7 days with methoxyphenamine alone or in combination with either sparteine or quinidine, gave N-desmethylmethoxyphenamine and its N-acetyl conjugate as major metabolites, while O-desmethylmethoxyphenamine, 5-hydroxymethoxyphenamine and 2-hydroxyamphetamine were produced in lesser amounts. In addition, 1-(2-hydroxyphenyl)-2-aminopropane, 1-hydroxy-1-(2-methoxyphenyl)-2-propanone, β-hydroxymethoxyphenamine, and 1-(5-hydroxy-2-methoxyphenyl)-2-aminopropane were tentatively identified as minor components of the fungal biotransformation of methoxyphenamine.

2. As observed in mammalian systems, the addition of either sparteine or quinidine decreased the rate and extent of methoxyphenamine biotransformation.

3. C. bainieri, may be a useful model for drug interaction studies.

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