Ethacizin Metabolism in Humans

V. L. Beloborodov I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

A. P. Rodionov I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

N. A. Tyukavkina I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

A. V. Klimov I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

N. V. Kaverina I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

YU. A. Kolesnik I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

A. N. Gritsenko I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

V. P. Lesina I. M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology of the Academy of Medical Sciences of the USSR, Moscow

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Abstract

1. The major metabolites of ethacizin (ethyl 10-[3-diethylaminopropionyl]pheno-thiazine-2-carbamate) have been isolated from human urine by h.p.l.c. and identified by determination of u.v., i.r., n.m.r. and mass spectra and comparison with spectra of synthetic standard compounds.

2. The pathways of metabolism of ethacizin include N-de-ethylation, sulphoxidation, N-10 amide hydrolysis, aromatic hydroxylation and conjugation.

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Ethacizin Metabolism in Humans

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Ethacizin Metabolism in Humans

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