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Abstract
1. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied.
2. DGBA (5 mm) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of < 3 min.
3. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level.
4. No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats.