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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 12
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Original Article

Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite

P. Voncken INBIFO Institut für biologische Forschung, Fuggerstrasse 3, D-5000, Körln 90, FRG
,
K. Rustemeier INBIFO Institut für biologische Forschung, Fuggerstrasse 3, D-5000, Körln 90, FRG
&
G. Schepers INBIFO Institut für biologische Forschung, Fuggerstrasse 3, D-5000, Körln 90, FRG
Pages 1353-1356 | Published online: 27 Aug 2009
 
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Abstract

1. cis-3'-Hydroxycotinine was detected as an S(-)-nicotine metabolite in the urine of smokers as well as in the urine of rats and hamsters dosed with nicotine.

2. The excreted amount of cis-3'-hydroxycotinine is lower than that of the trans-isomer.

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