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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 1
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Original Article

The disposition of tert-butyl-D-serine in the rat

S. Knott Drug Metabolism Section, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
A. Warrander Drug Metabolism Section, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
P. J. Phillips Drug Metabolism Section, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
&
J. R. Harding Drug Metabolism Section, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
Pages 1-5 | Received 02 Mar 1989, Accepted 30 Jul 1989, Published online: 27 Aug 2009
 
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Abstract

1. Following intravenous administration of 14C-tert-butyl-D-serine to rats, radioactivity was eliminated rapidly via the kidneys.

2. One metabolite was detected in urine and was identified as the N-acetyl derivative of tert-butyl-serine.

3. Elimination was more rapid in female than male rats.

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