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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 6
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Original Article

Biliary excretion and intestinal metabolism in the intermediary metabolism of pentachlorothioanisole

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Pages 601-605 | Received 05 Aug 1989, Accepted 15 Feb 1990, Published online: 27 Aug 2009
 

Abstract

1. Biliary metabolites from rats dosed with pentachlorothioanisole (PCTA) were characterized by fast atom bombardment mass spectrometry and electron impact mass spectrometry.

2. Most of the biliary metabolites from PCTA were mercapturic acid pathway metabolites of methylsulphinyltetrachlorobenzene (51% of the dose); the remaining characterized biliary metabolites (20%) were mainly methylsulphinyltetrachlorothio-phenols excreted as unknown conjugates.

3. Pathways are proposed for the intermediary metabolism of PCTA to bis-(methylthio)tetrachlorobenzene (bis-MTTCB) involving glutathione conjugation, biliary excretion, intestinal metabolism, and enterohepatic circulation.

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