Review Reactive oxygen and glomerular dysfunction

Abstract

1. The function of the kidney glomerulus, and the formation of reactive oxygen species in the glomerulus, is reviewed.

2. Experimental models of glomerular injury, resulting from immunological and nonimmune reactions, are known to give rise to morphological and functional changes of the glomerulus, resulting in proteinuria.

3. From the use of oxygen radical scavengers and inhibitors, glomerular injuries have been shown to be associated with the production of hydrogen peroxide, hydroxyl radical, and superoxide anion radical.