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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 2
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Research Article

Bioavailability, disposition and pharmacokinetics of 14C-ormetoprim in rainbow trout (Salmo gairdneri)

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Pages 147-157 | Received 10 Jan 1989, Accepted 05 Sep 1989, Published online: 22 Sep 2008
 

Abstract

1. Uptake, bioavailability, tissue disposition, and elimination of 14C were examined in rainbow trout following intravascular and per os dosing of 14C-ormetoprim (8mg/kg).

2. Plasma clearance was rapid following a single i.v. dose (t1/2α=0.54 h, t1/2β=17.5 h) with an apparent volume of distribution (Vss) of 4.851/kg. An increase in both t1/2α (0.67 h) and t1/2β (36.7 h) was seen following multiple i.v. doses (steady state).

3. Oral dispositional studies revealed the highest concentration of OMP in bile, kidney and liver, indicating significant renal and hepatic extraction. Significant OMP residues were seen in skin (0.90 p.p.m.) and muscle (0.15 p.p.m.) at 38 days.

4. Peak absorption time of orally administered OMP was 12h with an apparent bioavailability of 87%.

5. Intravascularly administered OMP was 33% and 31% protein-bound at 1 and 6h respectively, and binding was non-specific and non-saturable by Scatchard analysis.

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