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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 3
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Research Article

Metabolism in the rat of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine

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Pages 371-382 | Received 11 Apr 1990, Accepted 07 Sep 1990, Published online: 22 Sep 2008
 

Abstract

1. The metabolism of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine (BMC) administered to rat at 10 mg/kg has been studied using a combination of radio-t.l.c. and h.p.l.c.

2. The major route of excretion for the administered 14C was via the urine (79% in 3 days).

3. The major metabolite was hippuric acid. The extent of biotransformation of BMC indicated the lability of the N-malonyl bond whose hydrolytic removal initiated a metabolic sequence which involved the action of C-S lyase to produce benzyl thiol.

4. A comparison of the findings from this study with those from experiments with N-acetyl-S-benzyl-L-cysteine and S-benzyl-L-cysteine is made to support the metabolic pathway proposed.

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