Glutathione-S-transferase-medtated xnethylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats

Abstract

1. The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group.

2. Metabolites of the displaced methylthio group were methanesulphinic acid and sulphate in the urine, carbon dioxide in the expired air, and unidentified sulphur-containing compounds in the bile.