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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 9
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Research Article

Metabolism of benzothiazole. I. Identification of ring-cleavage products

, , , , &
Pages 1179-1183 | Received 03 Sep 1990, Accepted 12 Apr 1991, Published online: 22 Sep 2008
 

Abstract

1. The metabolic fate of benzothiazole in guinea pig has been investigated following i.p. administration at a dose of 30mg/kg.

2. Five ring-cleavage products were identified in urinary extracts by g.l.c.-mass spectra. By reference to authentic compounds the three major metabolites were shown to be 2-methylmercaptoaniline (I), 2-methylsulphinylaniline (II) and 2-methylsulphonylaniline (III). On the basis of the mass spectrometric evidence the remaining two metabolites were postulated to be 2-methylsulphinylphenylhydroxylamine (IV) and 2-methylsulphonyl-phenylhydroxylamine (V).

3. I, II and III were present in conjugated and unconjugated forms; IV and V were identified only after hydrolysis with sulphatase.

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