Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
5
Views
10
CrossRef citations to date
0
Altmetric
Research Article

The role of age and sex hormones on the urinary excretion of zenarestat in rats

, , &
Pages 1273-1279 | Received 09 Oct 1990, Accepted 12 Mar 1991, Published online: 22 Sep 2008
 

Abstract

1. Age-dependent changes in urinary excretion of zenarestat and the effect of gonadectomy and androgen treatment were investigated in Sprague—Dawley rats.

2. Urinary excretion of zenarestat scarcely differed between 3-week-old male and female rats; it decreased in males from 4 weeks of age, but in females urinary excretion of the drug was essentially constant during ageing.

3. Castration of male rats at 22 days of age abolished the adult sex difference in urinary excretion of zenarestat, while castration at 5 weeks of age produced urinary excretion of the drug about half that in females.

4. Ovariectomy of females at 22 days or 5 weeks of age had no effect on the urinary excretion of zenarestat.

5. Treatment of male and female gonadectomized rats with testosterone resulted in the urinary excretion of zenarestat characteristic of intact adult male rats.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.