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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 10
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Research Article

Hydroxylation and glucoside conjugation in the microbial metabolism of the diterpene sclareol

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Pages 1311-1323 | Received 25 Nov 1990, Accepted 01 Jun 1991, Published online: 22 Sep 2008
 

Abstract

1. The microbial metabolism of sclareol (1), a labdane diterpene ditertiary alcohol, was studied. Preliminary screening identified a number of microorganisms capable of metabolizing sclareol.

2. Preparative scale fermentation of growing cultures of Bacillus cereus UI-1477 resulted in the production of seven metabolites which have been characterized as 3β-hydroxysclareol (2), 2α-hydroxysclareol (3), 18-hydroxysclareol (4), 2α, 18-dihydroxysclareol (6), 8α,13β-dihydroxy-labd-14-en-3β-O-β-D-glucoside (5), 8α,13β-dihydroxy-labd-14-en-18-O-β-D-glucoside (7), and 8α,13β-dihydroxy-labd-14-en-2α-O-β-D-glucoside (10) by chemical, enzymic, and spectral data, especially 2D-n.m.r. techniques and thermospray liquid chromatography-mass spectrometry analysis.

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