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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 11
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Research Article

Identification of novel phencyclidine metabolites formed in vitro by rabbit microsomal metabolism

, , , , &
Pages 1493-1499 | Received 06 Dec 1990, Accepted 28 Jun 1991, Published online: 22 Sep 2008
 

Abstract

1. Phencyclidine (PCP) was incubated with rabbit liver and brain microsomal fractions, and the structures of metabolites formed by oxidation determined by g.l.c.-mass spectrometry.

2. The formation of several known mono- and di-hydroxylated metabolites, as well as two new metabolites, was seen in the liver preparations.

3. Hydroxylated PCP metabolites were also formed after incubation of PCP with brain microsomes, indicating that PCP biotransformation may occur in the brain itself.

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