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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 3
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Original Article

Stereoselective conjugation of a uricosuric diuretic with glutathione by glutathione transferase 3-3

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Pages 319-323 | Received 14 May 1991, Accepted 25 Oct 1991, Published online: 27 Aug 2009
 

Abstract

1. The activity of glutathione (GSH) transferases in rat liver cytosol was inhibited by the (-) enantiomer of a uricosuric diuretic (6,7-dichloro-5[N,N-dimethylsulphamoyl]-2,3-dihydrobenzofuran-2-carboxylic acid, DBCA) in a concentration-dependent manner. Although the DBCA (+) enantiomer inhibited the activity of liver cytosol GSH transferases, it was less effective.

2. Among four purified GSH transferase isozymes obtained from rat liver cytosol, isozyme 3–3 showed stereoselective interactions with the enantiomers of DBCA. This isozyme most actively and preferentially catalysed the transfer of GSH to DBCA (-) enantiomer.

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