Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle

C. E. Lanusse Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0

B. Nare Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0

L. H. Gascon Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0

R. K. Prichard Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste-Anne de Bellevue, Québec, Canada, H9X 1C0

Abstract

1. The metabolism of albendazole (ABZ), albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO₂) by ruminal, abomasal and ileal fluids of sheep and cattle was investigated under anaerobic conditions in vitro.

2. None of the compounds was metabolically changed by incubation with abomasal fluids of sheep and cattle.

3. ABZ and ABZSO were extensively metabolized by sheep and cattle ruminal and ileal fluids. ABZSO₂ was unaffected by incubation with these gastrointestinal fluids.

4. The rate of ABZ oxidation into ABZSO was greater for cattle ruminal and ileal fluids than for sheep fluids.

5. ABZSO was reduced back to ABZ by ruminal and ileal fluids of both species. This reducing activity was significantly higher for both ruminal and ileal fluids of sheep compared with those of cattle.

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Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle

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Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle

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