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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 5
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Research Article

The interaction of phosphine with haemoglobin and erythrocytes

K. L. Chin Department of Pharmacology and School of Science and Mathematics, University of Melbourne, Parkville, 3052, Australia
,
X. Mai Department of Pharmacology and School of Science and Mathematics, University of Melbourne, Parkville, 3052, Australia
,
J. Meaklim Department of Pharmacology and School of Science and Mathematics, University of Melbourne, Parkville, 3052, Australia
,
G. R. Scollary Department of Pharmacology and School of Science and Mathematics, University of Melbourne, Parkville, 3052, Australia
&
D. D. Leaver Department of Pharmacology and School of Science and Mathematics, University of Melbourne, Parkville, 3052, Australia
Pages 599-607 | Received 28 Aug 1991, Accepted 24 Jan 1992, Published online: 22 Sep 2008
 
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Abstract

1. Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent.

2. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate.

3. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process.

4. Uptake of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.

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