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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 11
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Miscellaneous Article

Mercapturic acid formation from 2-aminopyrazine in rats

W. H. W. Lunn Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, 46285, USA
&
J. K. Shadle Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, 46285, USA
Pages 1239-1241 | Received 20 Apr 1992, Accepted 30 Apr 1992, Published online: 23 Apr 2010
 
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Abstract

1. The compound 2-aminopyrazine was given by oral gavage to normal rats and their urine collected.

2. A mercapturic acid containing the 2-aminopyrazine moiety was isolated from this urine. This represents the first example of this type of a metabolite from a pyrazine.

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