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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 12
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Research Article

Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes

D. W. Kelly National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
,
C. L. Holder National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502
,
W. A. Korfmacher National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
,
T. A. Getek National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502
,
J. O. Lay National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502
,
D. A. Casciano National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
,
J. G. Shaddock National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502
,
H. M. Duhart National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502
&
W. Slikker National Center for Toxicological Research, Jefferson, Arkansas, 72079-9502; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
 show all
Pages 1367-1381 | Received 19 Nov 1991, Accepted 24 Jun 1992, Published online: 22 Sep 2008
 
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Abstract

1. Suspension cultures of freshly isolated F344 rat and B6C3F1 mouse hepatocytes were compared for their ability to transform various concentrations of methapyrilene (MP).

2. MP metabolites were isolated and purified by h.p.l.c., and were identified by comparing their chromatographic and mass spectral properties with those of authentic standards.

3. Both rat and mouse hepatocytes transformed MP to tentatively identified 2-thiophenecarboxylic acid (I), and definitively identified mono-N-desmethyl methapyrilene glucuronide (II), methapyrilene glucuronide (III), methapyrilene N-oxide (V), and mono-N-desmethyl methapyrilene (VII).

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