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Abstract
1. The effect of pretreatment of rats with the peroxisome proliferator 2,4,5-trichloro-phenoxyacetic acid (2,4,5-T) on sulphobromophthalein excretion from the isolated perfused rat liver has been investigated and compared with the effect of clofibrate which is also a peroxisome proliferator.
2. Rats fed 2,4,5-T at a dose of 0˙25% in the diet showed a decrease in food intake, compared with controls and clofibrate-fed rats.
3. Treatment with either 2,4,5-T or clofibrate was associated with significant inhibition of the biliary excretion of unchanged, conjugated, and total sulphobromophthalein from perfused rat liver, compared with diet-matched controls.
4. There was a decrease in bile flow in the clofibrate-treated group, but not in the 2,4,5-T-treated group.
5. The results of the present study confirm previous studies that have shown an association between peroxisome proliferation treatment and inhibition of glutathione S-transferase-mediated sulphobromophthalein excretion.