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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 1
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Research Article

The metabolism of 2,3,7,8-tetrabromodibenzodioxin in the rat

J. de Jongh Research Institute of Toxicology, University of Utrecht, PO Box 80176, 3508 TD, Utrecht, The Netherlands
,
H. R. Buser Swiss Federal Research Station, CH-8820, Waedenswil, Switzerland
&
H. Poiger Institute of Toxicology, Federal Institute of Technology and University of Zurich, CH-8603, Schwerzenbach, Switzerland
Pages 19-26 | Received 17 Mar 1992, Accepted 30 Jul 1992, Published online: 22 Sep 2008
 
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Abstract

1. 2,3,7,8-Tetrabromodibenzodioxin was administered to bile-duct-cannulated rats in a single oral dose.

2. The compound was metabolized in the liver and metabolites were secreted into the bile.

3. Several phenolic metabolites were identified as their methyl ether derivatives by gas chromatography-mass spectrometry after clean-up and methylation of bile samples.

4. The main metabolites were formed by aromatic hydroxylation and via displacement of Br-substituents (hydrolytic debromination).

5. Trace amounts of unmetabolized TBDD were also present in the bile.

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