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Abstract
1. 3,3′,4,4′-Tetrachlorobiphenyl (TCB) induces liver microsomal 7-ethoxyresorufin-O-deethylase (EROD) activity, and this P450 isoform, i.e. CYP 1, is involved in the metabolism of TCB.
2. TCB administered i.p. to pregnant mice (5-25mg/kg) induced foetal as well as maternal hepatic EROD activity; in all cases the maternal induced activity was higher than the foetal activity. EROD activity of TCB-induced foetuses increased with developmental age, but decreased with the length of time after treatment.
3. Strain differences were seen; in control mice and TCB-treated dams NMRI>C57BL in EROD activity, but in transplacentally TCB-treated foetuses, C57BL>NMRI. EROD activity in non-pregnant control C57BL mice was higher than in pregnant ones, whereas no activity was seen in control foetuses.
4. Results indicate that TCB at a certain dose can induce foetal metabolism, but that earlier observed foetal accumulation at lower TCB doses is probably a consequence of transplacental transport of maternally-produced metabolites.