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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 3
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Research Article

Effects of phenolic compounds on bromobenzenemediated hepatotoxicity in mice

M. PayÁ Departamento de Farmacología, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, Burjassot, Valencia, 46100, Spain
,
M. L. Ferrandiz Departamento de Farmacología, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, Burjassot, Valencia, 46100, Spain
,
M. J. Sanz Departamento de Farmacología, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, Burjassot, Valencia, 46100, Spain
&
M. J. Alcaraz Departamento de Farmacología, Facultad de Farmacia, Avda. Vicent Andrés Estellés s/n, Burjassot, Valencia, 46100, Spain
Pages 327-333 | Received 10 Jun 1992, Accepted 14 Oct 1992, Published online: 22 Sep 2008
 
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Abstract

1. The hepatic protective effects of the phenolic compounds 7,8-dihydroxyflavone, morin, silymarin, caffeic acid and chlorogenic acid on bromobenzene-induced toxicity in mice were studied.

2. Morin, caffeic acid and chlorogenic acid at an oral dose of 200mg/kg failed to influence hepatotoxicity in vivo, while 7,8-dihydroxyflavone exhibited efficacy and potency higher than those of the reference compound silymarin.

3. 7,8-Dihydroxyflavone, an antioxidant and hepatoprotective agent in vitro, decreased serum glutamate-pyruvate transaminase levels (SGPT) in a dose-related manner, and at 200mg/kg inhibited bromobenzene-induced glutathione depletion in liver.

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