Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat

J. E. Bakke US Department of Agriculture, Agriculture Research Service, Biosciences Research Laboratory, Fargo, ND, 58105, USA

D. J. Mulford US Department of Agriculture, Agriculture Research Service, Biosciences Research Laboratory, Fargo, ND, 58105, USA

J. K. Huwe US Department of Agriculture, Agriculture Research Service, Biosciences Research Laboratory, Fargo, ND, 58105, USA

V. J. Feil US Department of Agriculture, Agriculture Research Service, Biosciences Research Laboratory, Fargo, ND, 58105, USA

K. L. Davison US Department of Agriculture, Agriculture Research Service, Biosciences Research Laboratory, Fargo, ND, 58105, USA

Abstract

1. Sex differences observed in the metabolism of pentachlorothioanisole in rat were due to: (1) greater excretion in urine by females, and greater biliary excretion by males; (2) formation of pentachlorophenyl mercapturic acid pathway metabolites by females; and (3) redox-cycling between methylthio and methylsulphoxyl oxidation congeners in intermediary metabolites by females.

2. Three methylthio-turnover processes are proposed in the intermediary metabolism of pentachlorothioanisole.

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Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat

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Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat

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