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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 5
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Research Article

Metabolism of tetramethrin isomers in rat. I. Identification of a sulphonic acid type of conjugate and reduced metabolites

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Pages 473-484 | Received 19 Nov 1993, Published online: 22 Sep 2008
 

Abstract

1. Urinary and faecal metabolites in rat treated with 14C-labelled (1 RS, trans)-tetramethrin [3,4,5,6-tetrahydrophthalimidomethyl (1 RS, trans)-chrysanthemate] were identified using chromatographic techniques and spectroanalyses (nmr and ms).

2. 3-Hydroxy-cyclohexane-1,2-dicarboximide was found to be a major and unique urinary metabolite, reduced at the 1,2-double bond of the 3,4,5,6-tetrahydrophthalimide moiety.

3. The major faecal metabolites were sulphonic acid conjugates, having a sulphonic acic group incorporated into the double bond of the 3,4,5,6-tetrahydrophthalimide moiety.

4. On the basis of the metabolites identified here, the major biotransformation reactions of trans-tetramethrin in rats are: (1) cleavage of the ester linkage; (2) cleavage of the imide linkage; (3) hydroxylation of the cyclohexene or cyclohexane ring of the 3,4,5,6-tetrahydrophthalimide moiety; (4) oxidation at the methyl group of the isobutenyl moiety; (5) reduction at the 1,2-double bond of the 3,4,5,6-tetrahydrophthalimide moiety; and (6) incorporation of a sulphonic acid group into the 1,2-double bond of the 3,4,5,6-tetrahydrophthalimide moiety.

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