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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 4
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Research Article

Fate of dimethylamine in man

, , , &
Pages 379-387 | Received 19 Nov 1993, Published online: 22 Sep 2008
 

Abstract

1. The fate of [14C]-dimethylamine was investigated following oral administration to four male volunteers.

2. The major route of excretion was urine, with 94% of the administered radioactivity being voided over 3 days (87% during the first 24 h). Small amounts (1-3%) of radioactivity were found in the faeces and expired air.

3. Metabolism was limited with only 5% being demethyiated to methylamine. The remainder of the dose was excreted unchanged.

4. Pharmacokinetic studies indicated rapid (t1/2ab = 8 min) and extensive absorption (bioavailability = 82%) from the gastrointestinal tract followed by widespread distribution and a fairly prompt excretion (t1/2el = 6-7h) with a plasma clearance of 190 ml/min.

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