Disposition of phenol in rat after oral, dermal, intravenous, and intratracheal administration

Abstract

1. The absorption and elimination of [¹⁴C]-phenol (63.5 nmol) after oral, dermal, intratracheal, or intravenous administration in rat was rapid and extensive. Urinary elimination of radioactivity predominated, with a range of 75–95% of the dose detected in urine by 72 h post-exposure.

2. Washing the dermal site 72 h post-exposure removed 14% of the dose. Two per cent of the dose was detected in the skin.

3. The urinary metabolites at 4 and 8 h after administration by the four routes included phenyl sulphate and lower amounts of phenyl glucuronide.

4. Phenol was poorly retained in the body after administration by the four routes. Phenol remaining in the body was widely distributed, with accumulation primarily in the liver, lung, and kidney.