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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 2
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Research Article

Plasma and urinary metabolites of efonidipine hydrochloride in man

, , , &
Pages 229-239 | Received 21 Aug 1995, Published online: 22 Sep 2008
 

Abstract

1. The plasma and urinary metabolite profiles of efonidipine hydrochloride, a new dihydropyridine calcium antagonist, have been examined in six healthy male volunteers after oral dosing.

2. Unchanged drug in plasma was determined by hplc-ms. Five metabolites in plasma and five metabolites and unchanged drug in urine were identified by hplc.

3. The main plasma metabolites were N-dephenylated-efonidipine and deaminated-efonidipine.

4. No significant amount of unchanged drug was excreted in urine. In the urine collected for 24 h after a oral dosing, 1.1% of the dose was excreted as deaminated-efonidipine, and 0.5% as a pyridine analogue of deaminated-efonidipine.

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