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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 9
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Original Article

Use of site-specified tritium labelling to confirm the formation of 17-oxosparteine as a minor urinary metabolite of sparteine in man

J. C. Ritchie Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
,
S. C. Mitchell Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
,
R. L. Smith Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
&
A. Q. Zhang Pharmacology and Toxicology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK
Pages 977-982 | Received 01 Dec 1996, Published online: 27 Aug 2009
 
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Abstract

1. The synthesis of [17, 17-3H2]-sparteine and its oral administration has enabled the specific identification of 17-oxosparteine as a minor urinary metabolite (∼ 1% dose) in two healthy male volunteers.

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