Mean platelet volume could be a useful biomarker for monitoring epithelial ovarian cancer

Abstract

New studies show that inflammatory markers and blood cells may be related to epithelial ovarian cancer (EOC). We aimed to examine whether mean platelet volume would be a useful marker for EOC patients to predict tumour burden and prognosis, and investigate the difference in MPV values between EOC patients and healthy controls. We retrospectively investigated 113 ovarian cancer patients who underwent surgery between January 2008 and July 2012 and 90 healthy subjects. MPV levels were significantly higher in preoperative EOC patients compared with healthy subjects (8.26 fl vs 7.71 fl; p = 0.004). Also NLR and PLR values were significantly higher in EOC patients (NLR, 3.48 vs 2.37; p = 0.000; PLR, 241 vs 148; p = 0.000). Surgical tumour resection resulted in a significant decrease in MPV levels (8.26 fl vs 7.61 fl; p = 0.001). NLR values also decreased after tumour resection significantly similar to CA125 (NLR, 3.48 vs 2.49; p = 0.000). Our data suggests that MPV could be a promising and easily available biomarker for monitoring EOC patients.

Keywords::

• Ovarian cancer
• platelets

Acknowledgements

We thank Professor Yuksel Bek and Dr Berkhan Topaktas for their advice on the statistical analyses.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.