Activity of coagulation factor XI in patients with spontaneous miscarriage: The presence of risk alleles

Abstract

The aim of this study was to compare the activity of coagulation factor XI (FXI) between patients with spontaneous miscarriage versus control group with no history of miscarriage and thrombosis, and then we evaluated the occurrence of risk alleles in the relation to miscarriage. FXI activity was determined using a coagulometer (Sysmex, CA 1500, Japan). Single nucleotide polymorphisms (SNPs) of F11 and CYP4V2 genes were evaluated. We examined 55 patients versus 31 control subjects. We found significantly higher activity of FXI (p = 0.04) in patients versus control subjects. The occurrence of two SNPs (rs2289252 and rs2036914) of the F11 gene and SNP (rs13146272) of CYP4V2 gene was not significantly different between both groups.

Increased activity of FXI may be a potential risk factor for miscarriage. High activity of FXI diagnosed in women with history of miscarriage is not probably caused by the presence of studied SNPs.

Keywords::

• Alleles
• factor XI
• single nucleotide polymorphism
• spontaneous miscarriage
• thrombophilia

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the review reported.

The study was supported by grants VEGA 1/0016/12, VEGA 1/0272/14 and APVV-0222-11.