Alterations in lipid peroxidation and T-cell function in women with hyperemesis gravidarum

Abstract

The objective of this study was to investigate serum adenosine deaminase (ADA) activity as a marker of T lymphocyte activation and parameters of oxidative stress and antioxidant defence in hyperemesis gravidarum (HG). Serum ADA activity, malondialdehyde (MDA), catalase (CAT) and glutathione peroxidase (GP_x) levels were investigated in 40 pregnant women with the HG and 40 with healthy pregnancies, in a descriptive study. Although serum ADA and CAT were measured to be higher in HG group, the difference was not significant. Serum MDA and GP_x levels were significantly elevated in women with HG when compared with those without HG. The significance of changes in lipid peroxidation and T-cell activation in the pathogenesis of HG and whether this is a cause or a compensatory reaction to HG requires further investigations with larger multicentre trials.

Keywords::

• Adenosine deaminase
• catalase
• glutathione peroxidase
• hyperemesis gravidarum
• malondialdehyde

Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.