Sex-hormone—binding globulin in the plasma of normal men and patients with benign prostatic hypertrophy

J. J. Minguell Division de Bioquimica y Biofisica, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, and the Servicio de Urologia, Hospital R. Barros Luco, Santiago, Chile

J. Merino Division de Bioquimica y Biofisica, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, and the Servicio de Urologia, Hospital R. Barros Luco, Santiago, Chile

L. E. Valladares Division de Bioquimica y Biofisica, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, and the Servicio de Urologia, Hospital R. Barros Luco, Santiago, Chile

S. Troncoso Division de Bioquimica y Biofisica, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, and the Servicio de Urologia, Hospital R. Barros Luco, Santiago, Chile

Abstract

Sex-hormone—binding globulin (SHBG) was measured in the plasma of normal men aged 30–50 yr, normal men 50–70 yr of age, and men 50–70 yr of age suffering from benign prostatic hypertrophy (BPH). The level of binding proteins in normal “young” men decreased approximately 45% in normal “older” men. A 100% rise was observed in BPH patients as compared to normal older men. This increase seemed to be related to a rise in SHBG and also to the appearance of binding species of smaller molecular weight than that of SHBG.

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Sex-hormone—binding globulin in the plasma of normal men and patients with benign prostatic hypertrophy

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Sex-hormone—binding globulin in the plasma of normal men and patients with benign prostatic hypertrophy

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