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Archives of Andrology
Journal of Reproductive Systems
Volume 3, 1979 - Issue 2
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Original Article

Methotrexate and fertility in men

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Pages 177-179 | Received 05 Feb 1979, Published online: 09 Jul 2009
 

Abstract

The possible deleterious effects of folic acid antagonist methotrexate on the fertility potential have been investigated in 26 male psoriatic patients. Examination for semen, testicular histology, and spermatogenic function using radioactive phosphorus revealed that methotrexate had no unfavorable effect on male fertility. A long follow up of the patients and their offspring is needed to exclude the possible teratogenic effect of the drug.

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