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Abstract
Eight normal and 17 hypogonadal males were injected with human chorionic gonadotropin (hCG). In normal males at 48 hr testosterone and estradiol became, respectively, 160% and 338% of basal values. In hypogonadal males at 48 hr testosterone and estradiol became, respectively, 211% and 127% of basal values. No changes occurred in serum thyroid stimulating hormone (TSH), serum thyroxine (T4), and tri-iodothyronine (T3). The success of long-term therapy with hCG in five patients was predicted by the test.