Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 13, 1984 - Issue 2-3
129
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Original Article

Pharmacokinetics of Zinc Tannate After Intratesticular Injection

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Pages 129-136 | Received 16 Apr 1984, Published online: 09 Jul 2009
 

Abstract

Forty-eight sexually mature male rats were injected intratesticularly with either 1, 3, or 6 mg zinc tannate (Kastrin) or with saline (as control). Zinc localized only in low concentration in primary spermatocytes and could not be detected in spermatogonia, Sertoli cells, spermatids, or spermatozoa. Forty-eight hours after injection of 1 mg Kastrin, zinc was accumulated in the spermatogonia and primary spermatocytes while, after injection of 3 mg, zinc was preferentially localized in Sertoli cells and spermatids; however, zinc was observed in the spermatids and spermatozoa 48 h after injection iwth 6 mg, and germ cells lost their identity and were fragmented after 1 week.

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