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Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 15, 1985 - Issue 1
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Original Article

Tamoxifen and Oligospermia

I. Noci Department of Obstetrics and Gynecology, University of Florence, Florence, Italy
,
E. Chelo Department of Obstetrics and Gynecology, University of Florence, Florence, Italy
,
O. Saltarelli Department of Obstetrics and Gynecology, University of Florence, Florence, Italy
,
G. Donaticori Department of Obstetrics and Gynecology, University of Florence, Florence, Italy
&
G. Scarselli Department of Obstetrics and Gynecology, University of Florence, Florence, Italy
Pages 83-88 | Accepted 13 Dec 1984, Published online: 09 Jul 2009
 
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Abstract

Thirty normogonadotropic oligospermic males were administered Tamoxifen (20 mg/day) for 4 months. A complete evaluation of seminal parameters before and after treatment was performed. An increase of both mean sperm concentration and total sperm count was noted after treatment with Tamoxifen (p < 0.05), whereas no variation was observed for semen volume, sperm morphologic characteristics, or sperm motility. Hormonal patterns of 5 of these subjects before, during, and after 3 months of treatment with Tamoxifen showed a progressive increase of gonadotropin (especially LH) and 17/βE2 values; testosterone variations were minimal, and PRL showed a slight decrease.

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