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Publication Cover
Archives of Andrology
Journal of Reproductive Systems
Volume 21, 1988 - Issue 3
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Original Article

Effect of L-Carnitine on Motility and Acrosome Reaction of Human Spermatozoa

R. Deana Department of Biological Chemistry, C.N.R. Unit for the Study of Mitochondrial Physiology, University of Padova, Italy
,
M. Indino Institute of Semeiotica Medica, University of Padova, Italy
,
F. Rigoni Department of Biology, University of Padova, Italy
&
C. Foresta Institute of Semeiotica Medica, University of Padova, Italy
Pages 147-153 | Received 06 Apr 1988, Accepted 07 Jun 1988, Published online: 09 Jul 2009
 
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Abstract

L-carnitine added to the suspension medium decreases the glucose-sustained progressive motility of human spermatozoa. Addition of 20 mM L-carnitine to the capacitation medium causes an inhibition of the occurrence of the acrosome reaction parallel to a viability enhancement and negligible changes of the cellular content of ATP. The cellular efflux of glutamate-oxaloacetate transaminase was also inhibited by L-carnitine. A possible role of L-carnitine on membrane stability and metabolism of spermatozoa is briefly discussed.

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